The line up for the first Late Late Show of 2021 has been revealed for Friday's show.
Vicky Phelan will be telling viewers about her upcoming trip to the US for an experimental new treatment, and why she is preparing to risk spending six precious months away from her family in her fight to stay alive.
The women's health campaigner will be discussing why she hopes this treatment will give her the time she desperately needs, how the last nine months have helped her re-evaluate life, and why our frontline workers need our support now more than ever.
Meanwhile, host Ryan Tubridy will be joined by Paul Reid, the chief executive of the Health Service Executive, for an up-to-the-minute assessment of how our health system is coping under the impact of this latest surge in the Coronavirus pandemic and what the coming days and weeks will hold for anyone needing to access healthcare in Ireland.
Dr Colm Henry, the chief clinical officer of the HSE and NPHET member, will join Ryan live in studio to oversee the inoculation of six of Ireland's healthcare workers, against Covid-19 with the approved vaccine.
Dr Henry will explain how it works and when you can expect to receive your dose of the vaccine in the coming months.
Wexford Hurling manager Davy Fitzgerald is back with Ireland's Fittest Family and preparing for upcoming show Davy's Toughest Team, and he joins Ryan to discuss how the past year has changed his perspective on hurling and family.
He will also be discussing why recent events have led him to take a stand against online bullying.
Donie O'Sullivan, the CNN journalist from Kerry who was reporting live from Washington this week as chaos broke out across the US capital will also be chatting to Ryan.
There will also be music from Lucia Evans who will give a very special performance alongside the Discovery Gospel Choir.