Some 5,272 cases have been reported in the last seven days, bringing the overall total number of cases confirmed in the region to 18,190.
No further deaths have been reported by the department, leaving the toll at 587.
The seven-day infection rate per 100,000 in the Derry and Strabane council area is now 824.3, among the highest in Britain and Ireland.
It comes as Sinn Féin vice president Michelle O'Neill confirmed she was self-isolating after a family member tested positive for Covid-19.
The Deputy First Minister is awaiting a test for the virus.
A spokesperson for the party has said she will continue to carry out her duties within the Stormont Executive remotely.
Yesterday, Ms O’Neill said the Executive is “extremely concerned at the steep and dangerous curve of infection that we are now on.”
“We are past the point of warnings, this is real and it’s happening now,” she said.
“We’re not trying to alarm people but it’s important for us to get across in the strongest possible terms that we need your help, we’re appealing for everyone to take action now. We can all make a difference now.”
