The crash happened just before 3pm on Tuesday afternoon between junction 12 at Firhouse and junction 13 at Ballinteer.
Gardaí say the man was pronounced dead at the scene. Forensic crash investigators are on the way.
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Left lane and hard shoulder are now blocked S'bound between J12 Firhouse and J13 Dundrum due to a serious collision. Emergency services are on scene. #m50safety
— M50 Dublin (@M50Dublin) September 8, 2020
One lane is currently closed and there are delays on approach.
