A status yellow rainfall warning has been issued for all of Connacht as well as the counties of Donegal, Clare, Cork, Kerry and Limerick.
Met Éireann has said that "heavy and persistent rain" is set to fall over the 10 affected counties during the hours of the warning.
The alert will come into effect in the early hours of Thursday morning and last until 6am on Friday.
The forecaster has warned that these downpours may lead to some flooding and disruption.
Accumulations of 30mm to 60mm are expected widely, with higher values in mountainous regions.
Heavy and persistent rain overnight Wednesday through
to Friday morning will lead to some flooding and
disruption. Accumulations of 30mm to 60mm are
expected widely, with higher values in mountainous
regions. https://t.co/7aDQTqTyEp pic.twitter.com/dOAka3jlrj— Met Éireann (@MetEireann) October 27, 2020