The Belfast singer is due to perform with his band at Gosforth Park in Newcastle Upon Tyne, but said their appearance is not a "sign of compliance or acceptance of the current state of affairs" but rather a means of getting the band "out of the doldrums".
Concerts around the world have been cancelled or postponed due to restrictions on crowd sizes to curb the spread of Covid-19.
Major casualties in this year's music calendar include Glastonbury and the Reading Festival in the UK.
In a statement released on his website, Mr Morrison said socially distanced gigs were not economically viable and should not be the answer going forward.
He called on others in the industry to "come forward, stand up, fight the pseudo-science and speak up."
Mr Morrison said: "We need to be playing to full capacity audiences going forward.
"Sir Andrew Lloyd Webber and myself appear to be the only people in the music business trying to get it back up and running again," he added.
Gosforth Park have implemented social distancing rules to allow concerts to go ahead despite the virus, with Sam Fender playing two nights at the venue.
The venue allows for small groups to watch the concert from their own mini platform, ensuring a distance is maintained between groups.
Northern Irish band Two Door Cinema Club have also played the venue, while Ronan Keating is due to perform there in September.
Last weekend, a German research group carried out an experiment to determine how Covid-19 may spread at large gatherings, such as concerts.
Over 1,000 people took part in the study, in which various levels of social distancing were implemented, to look at whether these measures are effective.
The data from the study has not yet been released but researchers hope their findings will aid decision-making in the future.
