Goalkeeper Gavin Bazunu has received his first senior international call-up while Troy Parrott is included for the first time under Stephen Kenny as the Republic of Ireland squad was named for the opening 2022 World Cup qualifiers.
A 29-man squad has been named for the games.
In the absence of the injured Darren Randolph, Kenny has named four goalkeepers including 19-year-old Bazunu.
An update on Liverpool goalkeeper Caoimhin Kelleher's fitness is required before the players report for duty on Sunday.
Striker Aaron Connolly will also be assessed by the medical team on his injury after being named in the squad.
Ireland will travel to Serbia for their opening qualifying match at the Stadion Rajko Mitić, Belgrade on Wednesday, March 24th, with kick-off at 7.45pm, before returning to Dublin to face Luxembourg on Saturday, March 27th.
Ireland will then travel to the Nagyerdei Stadion, Debrecen, Hungary to face Qatar in an international friendly on Tuesday, March 30th.
The squad will report to Manchester on Sunday before flying to Belgrade on Monday afternoon ahead of the match on Wednesday.
Republic of Ireland squad — Serbia, Luxembourg & Qatar
Goalkeepers: Caoimhin Kelleher (Liverpool), Gavin Bazunu (Rochdale, on loan from Manchester City), Mark Travers (AFC Bournemouth), Kieran O'Hara (Burton Albion).
Defenders: Seamus Coleman (Everton), Matt Doherty (Tottenham Hotspur), Shane Duffy (Celtic, on loan from Brighton and Hove Albion), Enda Stevens (Sheffield United), Kevin Long (Burnley), Ciaran Clark (Newcastle United), Dara O'Shea (West Bromwich Albion), Ryan Manning (Swansea City), Cyrus Christie (Nottingham Forest).
Midfielders: Conor Hourihane (Swansea City, on loan from Aston Villa), Alan Browne (Preston North End), Jeff Hendrick (Newcastle United), Jayson Molumby (Preston North End, on loan from Brighton and Hove Albion), Jason Knight (Derby County), Josh Cullen (Anderlecht).
Wingers: Robbie Brady (Burnley), James McClean (Stoke City), Daryl Horgan (Wycombe Wanderers), Ronan Curtis (Portsmouth), Callum O'Dowda (Bristol City).
Strikers: Callum Robinson (West Bromwich Albion), Aaron Connolly (Brighton and Hove Albion), Shane Long (AFC Bournemouth, on loan from Southampton), James Collins (Luton Town), Troy Parrott (Ipswich Town, on loan from Tottenham Hotspur).
