Ed Woodward has resigned as Manchester United executive vice-chairman, the PA news agency understands.
The 49-year-old took the post at Old Trafford in 2013 and played a key role in the planning of a European Super League, which is now on the verge of collapse.
Woodward's decision to leave his position came after reports that Chelsea and Manchester City were pulling out of the planned breakaway which has received intense criticism and opposition.
The Manchester Evening News said Woodward would stay in his role until the end of the year despite offering his resignation.
United have been one of the leading clubs involved in the breakaway project and Woodward was singled out for criticism by the head of European soccer's governing body Aleksander Ceferin.
Additional reporting from Reuters
