Shamrock Rovers will be aiming to close the gap on rivals Bohemians when they meet in the Dublin derby in a sold out Tallght stadium.
After a slow start to the season, the champions have hit their stride, and are four points behind Bohemians going into tonight's game. Boheminas nine wins from 13 games has put them in a strong position for European football, and will be eager to lay down a marker with victory over Stephen Bradley's side.
In Turner's Cross, Cork City and St Patrick's Atheltic will be hoping to put a dramatic week behind them after both sides managers departed.
Colin Healy left Cork City, with Liam Buckley and Liam Kearney co-interm managers for tonight's game, with Jon Daly taking over from Tim Clancy.
Derry City will be hoping to get back to winning ways when they face Drogheda United, while UCD will be hoping to turn their performances into results when they travel to Shelbourne.
On Saturday, Sligo Rovers host Dundalk in the battle between fourth and fifth.
Here is all you need to know ahead of this weekend's Airtricity league action.
Friday May 5th
Shamrock Rover v Bohemians, Tallaght Stadium, RTÉ Two, 7.45.
Cork City v St Patrick's Athletic, Turner's Cross, LOITV, 7.45.
Drogheda United v Derry City, Weavers Park, LOITV, 7.45.
Shelbourne v UCD, Tolka Park, LOITV 7.45.
Saturday May 6th
Sligo Rovers v Dundalk, Showgrounds, LOITV,7.45.