The Premier League makes its return after two weeks off due to the international break, with some big games this weekend.
With pressure continuing to grow on Erik Ten Hag, Manchester United host Brentford on Saturday, with every game now a must win for the Dutch man.
Liverpool will look to continue their impressive start to the season when they face Chelsea, while Manchester City travel to Wolves.
At home, the incredible title race in the League of Ireland continues, with six teams still having a chance of winning the league.
Shelbourne, who are still top of the table despite a drop in form, host Waterford, with champions Shamrock Rovers traveling to Drogheda.
Stephen Kenny has remarkably put St Patrick's Athletic in chance for the title, and they host Galway United.
In GAA, eyes will be on Croke Park, as the proposd rule changes in football will be seen for the first time in the provincial games on Friday and Saturday.
In rugby, Leinster will loo to continue their 100 per cent start to the URC season when they face Connacht.
Munster will be aiming to bounce back from their defeat in Croke Park when they face the Stormers in South Africa, while Ulster face Ospreys.
Here is where you can watch all the action:
Friday October 18th
Sky sports Action: American Football: NFL – Denver Broncos @ New Orleans Saints. 12am.
Golf: European Tour – Andalusia Masters, Round 2. Sky Sports Golf. 1pm.
GAA: Connacht v Leinster in the Allianz Football Inter-Provincial Semi Final. 17:30, TG4.
GAA: Munster v Ulster in the Allianz Football Inter-Provincial Semi Final. 19:45, TG4.
Soccer: League of Ireland: Shelbourne v Waterford, Virgin Media Three: 19:30.
Saturday October 19th
Soccer: Premier League: Tottenham Hotspur v West Ham United, TNT Sports, 12:30.
Rugby: United Rugby Championship: Stormers v Munster, RTÉ Two, 16:30.
Soccer: Manchester United v Brentford. Premier Sports Ireland, 15:00.
Soccer: Premier League: Bournemouth v Arsenal, Sky Sports Main Event/Premier League, 17:30.
Rugby: United Rugby Championship: Connacht v Leinster, 19:30, TG4.
GAA: Football Interprovincial Championship Final, RTÉ Two, 19:30.
Formula One United States Grand Prix – Qualifying. Sky Sports Formula One. 22:00.
Sunday October 20th
Golf: European Tour – Andalusia Masters, Round 4. Sky Sports Golf. 10:00.
Football: Women’s Super League – Manchester City v Aston Villa. BBC Two. 12:00.
Football: Premier League: Wolverhampton Wanderers v Manchester City. Sky Sports Premier League. 14:00.
GAA: Dublin senior football final: Kilmacud Crokes v Cuala, TG4, 14:30.
American Football: NFL – Jacksonville Jaguars @ New England Patriots. ITV1. 13:00.
Football: Premier League: Liverpool v Chelsea. Sky Sports Premier League, 16:30pm.
Motorsport: Formula One United States Grand Prix – Race: Sky Sports Formula One.18:30pm.