Led by former Labour leader Jeremy Corbyn’s brother Piers, demonstrators chanted “stick your poison vaccine up your arse”, “take off your masks” and “we are the 99 per cent” as they walked down Oxford Street.
Some carried placards blaming the virus on the new 5G network, while others claimed the virus itself was a hoax.
The protest comes on the day London was placed in Tier 2 lockdown measures, meaning Londoners are now banned from meeting people from outside their household indoors, and a maximum of six outdoors.
Demonstrators took a detour to Rathbone Square to stand outside Facebook’s London headquarters, although nobody was able to tell the PA news agency if they were for or against the social media giant, which many have blamed for spreading pandemic misinformation.
The protest later came to a halt in Leicester Square outside the Imax theatre, although it was unclear why as they had originally stated they were heading for Downing Street.
Many of those gathered carried signs reading “my body, my choice”, a slogan borrowed from the pro-choice movement.
One of the organisers told a breakaway group outside Downing Street: “Man flu has closed our country and crushed our economy.”
Piers Corbyn, who has previously been fined the maximum £10,000 for his anti-lockdown protests, also took part in a demonstration in Soho on Friday night.
“We’re here to drink against the curfew,” he said.
“To oppose the lockdowns, to oppose job losses caused by lockdowns, to oppose all of of it.
“The whole lot should be lifted now.”