The incident happened in Berlin’s Hardenbergplatz, outside the Zoological Garden railway station, shortly after 7am on Sunday.
Berlin’s fire department said on Twitter that three of the pedestrians suffered serious injuries, and that a rescue helicopter was deployed to help.
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One casualty had to be resuscitated at the scene, the fire department said.
Police said the driver of the vehicle has been taken into custody and an investigation is under way, but that it appears the accident was caused by excessive speed and there are currently “no indications of a political or religious motivation”.