Hungary took the lead among its fellow EU nations as it began vaccinating its people against Covid-19 on Saturday.
It came a day ahead of roll-outs in several other countries including France, Germany and Spain, as the pandemic surges across the continent.
Mass vaccination across the European Union, home to almost 450 million people, would be a crucial step towards ending the pandemic that has killed more than 1.7 million around the world, crippled economies and destroyed businesses and jobs.
Hungary administered the vaccine, developed by Pfizer and BioNTech, to frontline workers at hospitals in the capital Budapest after receiving its first shipment of enough doses to inoculate 4,875 people.
The first worker to receive the shot was Adrienne Kertesz, a doctor at Del-Pest Central Hospital.
Hungary has reported 315,362 Covid-19 cases with 8,951 deaths. More than 6,000 people are still in hospital with Covid-19, straining the central European country's care system.
We do not dare travel before we get the vaccine
"We are very happy that the vaccine is here," Zsuzsa and Antal Takacs, a couple aged 68 and 75, said while playing table tennis in a Budapest park.
"We will get the vaccination because our daughter had a baby in France last month and we want to go see them. We do not dare travel before we get the vaccine," Zsuzsa said.
The Hungarian roll-out came a day before countries including France, Germany, Italy, Austria, Portugal and Spain are planning to begin mass vaccinations, starting with health workers.
The distribution of the Pfizer-BioNTech shot, which was first rolled out in Britain earlier this month, presents tough challenges. The vaccine uses new mRNA genetic technology, which means it must be stored at ultra-low temperatures of around -80 degrees Celsius.
New variant
France, which received its first shipment of the two-dose Pfizer-BioNTech vaccine on Saturday, will start administering it on Sunday in the greater Paris area and in the Burgundy-Franche-Comte region.
"We have 19,500 doses in total, which amounts to 3,900 vials. These doses will be stored in our freezer at minus 80 degrees (Celsius) and will be then distributed to different nursing homes and hospitals," said Franck Huet, head of pharmaceutical products for the Paris public hospital system.
The French government is hoping to get around one million people vaccinated in nursing homes during January and February, and then a further 14-15 million in the wider population between March and June.
The Pfizer-BioNTech vaccine was approved by the French medical regulator on Thursday.
France reported more than 20,000 new Covid-19 infections on Friday for the second day running, something not seen since November 20th. The seven-day moving average of daily new cases, which evens out reporting irregularities, is at a one-month high of 14,969.
France's number of confirmed Covid-19 cases now totals 2,547,771, the fifth-highest tally in the world, while its Covid-19 death toll stands at 62,427, the seventh-highest.
In a concerning development, the health ministry said on Friday that a man who recently arrived from London had tested positive for a new variant of the virus that has been spreading rapidly in southern England and is thought to be more infectious.
Spain, Germany, Portugal
In Spain, Madrid health authorities said on Saturday they had confirmed four cases of the new variant of the virus, as the country received its first deliveries of the vaccine.
The boxes arrived by truck at a storage facility near Madrid as dawn broke. Employees at Spain's medicines agency unpacked the vaccine, which is stored in dry ice, with gloved hands.
"Vaccination will start tomorrow in Spain, coordinated with the rest of Europe," Health Minister Salvador Illa wrote on Twitter. "This is the beginning of the end of the pandemic."
Doses will be taken by air to the Spanish islands and the North African enclaves of Ceuta and Melilla, and by road to other regions of the country, where a total of about 50,000 people have died from the disease.
Germany, meanwhile, said trucks were on their way to deliver the vaccine to care homes for the elderly, which are first in line to receive the vaccine on Sunday.
A window of hope has now opened
The number of confirmed Covid-19 cases in the country rose by 14,455 to 1,627,103, data from the Robert Koch Institute for infectious diseases showed on Saturday. More than 29,000 people have died in total.
The federal government is planning to distribute more than 1.3 million vaccine doses to local health authorities by the end of this year and about 700,000 per week from January.
"There may be a few hiccups at one point or another in the beginning, but that is quite normal when such a logistically complex process begins," said Health Minister Jensen Spahn.
In Portugal, a truck escorted by police dropped off the first batch of Covid-19 jabs at a warehouse in the country's central region. From there, the nearly 10,000 shots will be delivered to five big hospitals.
"It is a historic milestone for all of us, an important day after such a difficult year," Health Minister Marta Temido told reporters outside the warehouse.
"A window of hope has now opened, without forgetting that there is a very difficult fight ahead."
